Benign prostatic hyperplasia

Benign prostatic hyperplasia (BPH) is a slow progressing enlargement of the male prostatic gland. It is one of the the top 10 most diagnosed conditions in men over the age of 50 years1. More than half of men in their 60s and up to 90% of men in their 70s and 80s suffer from Lower Urinary Tract Symptoms (LUTS) caused by BPH.2

Why the prostate grows with age is still not fully understood. The enlargement is explained by a multi-factorial constellation of characteristics and risk factors such as: genetic factors, hormonal changes, secondary inflammation and scarring within the gland, diet, overweight and its relation to the metabolic syndrome, and anatomical changes.

All these events can be observed during the aging process.
Many urologists and researchers interpret the inflammatory process as a possible underlying mechanism for both the development of BPH and symptoms related to CP/CPPS and prostate cancer as well.

Lower Urinary Tract Symptoms related to BPH

  • Frequent need to urinate, both day and night (urgency).
  • Waking up at night to urinate (nocturia).
  • Weak urine flow.
  • Difficulty emptying the bladder completely.
  • One or more interruptions when urinating.
  • Urinary leakage.
  • An urge to urinate again soon after urinating.

A Swedish study on 3345 men suffering from Lower Urinary Tract Symptoms (LUTS) showed that 37% of these men mentioned that these symptoms negatively affected their quality of life- 77% answered that their relationship was negatively affected.3

1. Fenter et al Am J Manag Care 2006.
2. National Institute of Diabetes and Digestive and Kidney Diseases 2006.
3. Stranne J et al. Scandinavian Journal of Urology and Nephrology 2009;43:199-205.